Cardiovascular Effects of Endothelin.
نویسندگان
چکیده
منابع مشابه
Effects of endothelin-1 and homologous trout endothelin on cardiovascular function in rainbow trout.
The cardiovascular effects of endothelin (ET)-1 and the recently sequenced homologous trout ET were examined in unanesthetized trout, and vascular capacitance curves were constructed to evaluate the responsiveness of the venous system to ET-1. A bolus dose of 667 pmol/kg ET-1 doubled ventral aortic pressure; produced a triphasic pressor-depressor-pressor response in dorsal aortic pressure (P(DA...
متن کاملEndothelin receptors in teleost fishes: cardiovascular effects and branchial distribution.
By observing gill blood flow using epi-illuminating microscopy, in parallel with cardiovascular recordings and immunohistochemistry, we have tried to identify the receptor mediating endothelin (ET) type 1 (ET1)-induced pillar cell contraction in the lamellae of the Atlantic cod (Gadus morhua). Intra-arterial injection of the specific ET(B) receptor agonist BQ-3020 induced dose-dependent increas...
متن کاملRole of endothelin in cardiovascular disease.
Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it...
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Background:Cardiovascular effects of acute organophosphate (OP) poisoning are common. This study was aimed to assess the cardiovascular effects of OP poisoned patients in Nepal. Methods:This was a prospective hospital-based cross-sectional study of 115 acute OP poisoned patients presenting in emergency department of a tertiary care teaching hospital of central Nepal during November 2008 to Octo...
متن کاملEndothelin receptor blockers in cardiovascular disease.
The endothelin (ET) system is comprised of 4 active ETs, with ET-1 being the predominant isoform in the cardiovascular system. Because of the potent vasoconstricting and mitogenic effects of ET-1 and its involvement in various cardiovascular diseases, blockade of the ET receptor has received considerable attention. ET receptor antagonism has been demonstrated to be beneficial in patients with p...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1992
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.56.162